Description
Product Characteristics: Ectonucleotide pyrophosphatase 1 (ENPP1) is belongs to a family of nucleotide pyrophosphate phosphodiesterases. It contains a short amino-terminal cytoplasmic tail, a single transmembrane domain, and a large extracellular carboxyl-terminal domain. This cell surface enzyme generates inorganic pyrophosphate which regulates cell differentiation. It serves as a physiological inhibitor of pyrophosphate calcification at least in part by generating ePPi from the dephosphorylation of ATP. Inactivating mutations of ENPP1 are associated with generalized arterial calcification of infancy.
ENPP1 Antibody is developed in goat using a KLH-coupled synthetic peptide from C-terminal of human ENPP1 (Swiss Prot: P22413).
Target Information: This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]